Non-steroidal anti-inflammatory drugs (NSAIDs)
Non-steroidal anti-inflammatory drugs, or NSAIDs as this group of drugs are often called, are usually the first treatment you are given for your AS. By reducing inflammation, NSAIDs can help to control pain and joint stiffness. This group of drugs are more effective in relieving peripheral symptoms (such as those affecting joints of fingers, wrists, hips and ankles) and may have a limited effect on spinal symptoms.
There are a number of different NSAIDs available which include aspirin and ibuprofen. People’s responses to NSAIDs vary, so more than one NSAID may be tried before one that works best for you is found. NSAIDs generally come in tablet or capsule form and are usually taken by mouth.
Pain relief should start soon after taking the first dose with the full effect felt after about a week of treatment. However, it may take up to three weeks for the anti-inflammatory effect of the NSAID to fully work. They may also be prescribed along with other drugs.
Potential side effects from NSAIDs include stomach discomfort, nausea, diarrhoea and occasional bleeding. If these effects are experienced, you should seek advice from a doctor. As side effects are specific to individual treatments, it is important to check the patient information leaflet for any medication you use or talk to your healthcare team.